All Categories (1-3 of 3)

1. Cell Factory for Small Molecule Inducible Delivery of Low Dose IL-2

   Online Presentations | 31 Aug 2023 | Contributor(s):: Celsa Pachlhofer, Yafet Arefeayne, Rice University

   Autoimmune and inflammatory diseases are characterized by insufficient regulatory T cells (Treg), which play a central role in maintaining peripheral tolerance, preventing autoimmunity, and limiting chronic inflammation.  Treg cells depend on IL-2 for survival and maintenance of their...

2. Engineer and Manufacture Off-the-Shelf CAR-Natural Killer Cells for Targeted

   Online Presentations | 07 Oct 2022 | Contributor(s):: Xiaoping Bao

   Cancer is a major threat for humans worldwide, with over 18 million new cases and 9.6 million cancer-related deaths in 2018. Although most common cancer treatments include surgery, chemotherapy, and radiotherapy, unsatisfactory cure rates require new therapeutic approaches, particularly for...

3. [Illinois] Cancer Community Symposium 2012: T Cell Receptors For Potential Cancer Immunotherapy Applications: Single Chain T Cell Receptors Circumvent Mispairing with Endogenous TCR and Mediate T Cell Activity

   Online Presentations | 09 May 2012 | Contributor(s):: David H. Aggen

   To improve the immune response to cancer, gene therapy with tumor-specific T cell-receptors (TCRs) provides an attractive approach to effectively arm patients T cells for tumor cell destruction. A high-affinity TCR specific for an antigenic peptide-major histocompatibility complex (pepMHC) can be...