Golden Opportunities: Gold Nanoparticles for Biomedical Applications

By Catherine J. Murphy

Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL

Published on

Abstract

Richard A. Walton Lecture in Inorganic Chemistry

Gold nanoparticles exhibit brilliant colors that are size- and shape-dependent. In addition to their strong absorption of light through the visible and near-infrared, these nanomaterials elastically scatter light, and generate local electric fields and heat under resonant illumination. Many scientists are using these materials as active materials for bioimaging, chemical sensing, and photothermal ablation of tumors. However, as more and more nanomaterials become useful for biomedical applications, concerns about their long-term effects on living systems have been raised. In this talk I will discuss how these nanoparticles are prepared, how their surface chemistry can be tuned, how apparent cytotoxicity can be traced back to reagents in the synthesis rather than the particles per se, how protein orientation can be controlled on their surfaces, how cells respond to these virus-sized objects, and how the photothermal properties of these nanomaterials enable potential drug delivery applications.

Bio

Cathrine J. Murphy Professor Murphy received two B.S. degrees, one in chemistry and one in biochemistry, from the University of Illinois in 1986. She received her Ph.D. from the University of Wisconsin in 1990. From 1990-1993, she was first an NSF and then an NIH postdoctoral fellow at the California Institute of Technology. From 1993-2009 Professor Murphy was a faculty member in the Department of Chemistry and Biochemistry at the University of South Carolina. In August 2009 she joined the faculty of the Department of Chemistry at the University of Illinois.

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Cite this work

Researchers should cite this work as follows:

  • Catherine J. Murphy (2020), "Golden Opportunities: Gold Nanoparticles for Biomedical Applications," https://nanohub.org/resources/32078.

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Time

Location

4102 Brown Hall, Purdue University, West Lafayette, IN

Tags

Golden Opportunities: Gold Nanoparticles for Biomedical Applications
  • Golden Opportunities: Gold Nanocrystals for Biomedical Applications 1. Golden Opportunities: Gold Nan… 0
    00:00/00:00
  • Art Before Science 2. Art Before Science 159.55955955955957
    00:00/00:00
  • the plasmon 3. the plasmon 301.30130130130129
    00:00/00:00
  • Gold Nanorods: strong absorbers and scatterers 4. Gold Nanorods: strong absorber… 422.62262262262266
    00:00/00:00
  • The Promise of (Gold) Nanotechnology for Human Health 5. The Promise of (Gold) Nanotech… 570.13680347013678
    00:00/00:00
  • Seed-Mediated Growth 6. Seed-Mediated Growth 634.76810143476814
    00:00/00:00
  • Pushing plasmons further out 7. Pushing plasmons further out 761.09442776109449
    00:00/00:00
  • Beautiful particles! 8. Beautiful particles! 770.37037037037044
    00:00/00:00
  • Ag deposition 9. Ag deposition 793.0597263930598
    00:00/00:00
  • How close are we to the dream 10. How close are we to the dream 935.402068735402
    00:00/00:00
  • How close are we to the dream 11. How close are we to the dream 962.328995662329
    00:00/00:00
  • Mini rods 12. Mini rods 1026.9936603269937
    00:00/00:00
  • Mini rods 13. Mini rods 1096.8635301968636
    00:00/00:00
  • Mini rod bio-bonuses 14. Mini rod bio-bonuses 1159.8598598598599
    00:00/00:00
  • Why are nanoparticle preps so picky? 15. Why are nanoparticle preps so … 1264.964964964965
    00:00/00:00
  • Final surface: bilayer of quaternary ammonium surfactant 16. Final surface: bilayer of quat… 1432.3323323323325
    00:00/00:00
  • Applications 17. Applications 1520.8208208208209
    00:00/00:00
  • In addition to plasmons: Practical advantages of colloidal gold 18. In addition to plasmons: Pract… 1765.065065065065
    00:00/00:00
  • Brachytherapy 19. Brachytherapy 1797.6976976976978
    00:00/00:00
  • Commercial colloidal gold nanocrystals 20. Commercial colloidal gold nano… 1840.1067734401067
    00:00/00:00
  • Plasmon-enhanced bioimaging agents 21. Plasmon-enhanced bioimaging ag… 1892.3590256923592
    00:00/00:00
  • Silica spacer layer 22. Silica spacer layer 1952.952952952953
    00:00/00:00
  • Making silica shells 23. Making silica shells 2033.6670003336671
    00:00/00:00
  • 25 samples 24. 25 samples 2079.7464130797466
    00:00/00:00
  • time resolve data 25. time resolve data 2113.48014681348
    00:00/00:00
  • electric field 26. electric field 2161.7951284617952
    00:00/00:00
  • Color EELS spectrum images of the mesoporous silica coated particles 27. Color EELS spectrum images of … 2191.3913913913916
    00:00/00:00
  • Photothermal therapy: shine light, kill 28. Photothermal therapy: shine li… 2241.5415415415418
    00:00/00:00
  • antibody on a surface 29. antibody on a surface 2253.3533533533532
    00:00/00:00
  • TEM of bacterium 30. TEM of bacterium 2294.3276609943277
    00:00/00:00
  • What we didn't do 31. What we didn't do 2336.3697030363696
    00:00/00:00
  • A few words about photothermal molecular release 32. A few words about photothermal… 2398.1314647981317
    00:00/00:00
  • LeChatelier's Principle 33. LeChatelier's Principle 2404.8381715048381
    00:00/00:00
  • Biologics: pharmaceuticals that are derived from organisms/cells 34. Biologics: pharmaceuticals tha… 2440.8074741408077
    00:00/00:00
  • Light-induced delivery (or not!) of proteins 35. Light-induced delivery (or not… 2465.5321988655323
    00:00/00:00
  • Isothermal titration calorimetry 36. Isothermal titration calorimet… 2540.373707040374
    00:00/00:00
  • Au NRs that absorb at 808 nm 37. Au NRs that absorb at 808 nm 2569.86986986987
    00:00/00:00
  • Pop on, pop off 38. Pop on, pop off 2589.6563229896565
    00:00/00:00
  • Can we predict protein adsorption/desorption in complex media? 39. Can we predict protein adsorpt… 2609.743076409743
    00:00/00:00
  • FITC-BSA-rods and rhodamine-LYS-rods in 10% FBS 40. FITC-BSA-rods and rhodamine-LY… 2630.8975642308978
    00:00/00:00
  • Biomolecules to cells 41. Biomolecules to cells 2658.0580580580581
    00:00/00:00
  • Darkfield imaging of nanoparticle accumulation 42. Darkfield imaging of nanoparti… 2686.252919586253
    00:00/00:00
  • cellular motion 43. cellular motion 2787.6209542876209
    00:00/00:00
  • Hmmm. Side Effect: Changing Cell Behavior! 44. Hmmm. Side Effect: Changing Ce… 2823.28995662329
    00:00/00:00
  • Gene expression 45. Gene expression 2847.9145812479146
    00:00/00:00
  • Long-term cellular exposures 46. Long-term cellular exposures 2896.996996996997
    00:00/00:00
  • Cells after 5 months 47. Cells after 5 months 2974.3743743743744
    00:00/00:00
  • Untitled: Slide 48 48. Untitled: Slide 48 2997.3640306973643
    00:00/00:00
  • Big conclusion: cells can adapt over time to NP exposure 49. Big conclusion: cells can adap… 3048.5151818485151
    00:00/00:00
  • Mechanism(s)? 50. Mechanism(s)? 3082.2822822822823
    00:00/00:00
  • Omics data can lead to testable hypotheses 51. Omics data can lead to testabl… 3153.8872205538873
    00:00/00:00
  • Molecular control of protein display 52. Molecular control of protein d… 3180.9809809809813
    00:00/00:00
  • What have we learned? 53. What have we learned? 3243.9439439439439
    00:00/00:00
  • Thank You 54. Thank You 3324.3576910243578
    00:00/00:00