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Illinois BioNanotechnology Seminar Series Spring 2011: Engineering Cellular Microenvironments for Biomedicine
Online Presentations | 14 Apr 2011 | Contributor(s): Brendan Harley
The extracellular matrix (ECM) is a complex organization of structural proteins such as collagens and proteoglycans. Heterogeneous tissues with spatially and temporally modulated properties and their biomaterial mimics play an important role in organism physiology and regenerative medicine. With...
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Illinois BioNanotechnology Seminar Series Spring 2011: Development of Anticancer Medicine
Online Presentations | 14 Apr 2011 | Contributor(s): Jianjun Cheng
Nanoparticles are promising carriers for the delivery of chemotherapeutics for cancer therapy. This presentation explores new developments in chemical and engineering processes to prepare anticancer nanomedicines.
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Illinois BioNanotechnology Seminar Series Spring 2011: Imaging Microvascular Blood Flow with MRI
Online Presentations | 05 May 2011 | Contributor(s): Brad Sutton
Blood flow in the brain is an important physiological quantity relating to vitality of brain tissue and performance of cognitive tasks. Current non-invasive methods to measure cerebral blood flow with magnetic resonance imaging (MRI) allow for the measurement of delivery of blood from feeding...
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Illinois BioNanotechnology Seminar Series Fall 2011: In vitro Cancer Metastasis Driven by Elasticity of Micro-environment
Online Presentations | 27 Oct 2011 | Contributor(s): Xin Tang
Cancer deaths are primarily caused by metastases, not by the parent tumor. However, the physical-chemical mechanisms and parameters within the cellular micro-environment that initiate the onset of metastasis, are not understood. Here we show that human colon carcinoma (HCT-8) cells can exhibit a...
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Illinois BioNanotechnology Seminar Series Fall 2011: Magnetomotive Molecular Nanoprobe
Online Presentations | 27 Oct 2011 | Contributor(s): Stephen Boppart
The diagnostic, interrogational, and therapeutic potential of molecular nanoprobes is rapidly being investigated and exploited across virtually every biomedical imaging modality. While many types of probes enhance contrast or delivery therapy by static localization to targeted sites, significant...
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Illinois BioNanotechnology Seminar Series Fall 2011: Multi-Modal and Multi-Functional Magnetic Particles for Cancer Imaging
Online Presentations | 27 Oct 2011 | Contributor(s): Adeel Ahmad
Differential adhesion between cadherin subtypes expressed on cell surfaces is postulated to direct cell segregation during tissue morphogenesis. The studies described here used magnetic twisting cytometry and traction force microscopy to test the impact of cadherin binding selectivity on...
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Illinois BioNanotechnology Seminar Series Fall 2011: Precisely Size Controlled Drug-silica Nanoconjugate for Cancer Therapy
Online Presentations | 05 Dec 2011 | Contributor(s): Li Tang
Drug delivery nanomedicine, exemplified by micelles and nanoparticles roughly in the size range of 1-200 nm, have attracted much interest in the past 2-3 decades as alternative modalities for cancer treatment. The size of these drug delivery vehicles has been strongly correlated with their in...
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Illinois BioNanotechnology Seminar Series Fall 2011: Directed Blood Vessel Growth Using an Angiogenic Microfiber/Microparticle Composite Patch
Online Presentations | 05 Dec 2011 | Contributor(s): Ross J DeVolder
Therapeutic angiogenesis has emerged as a promising strategy to treat various acute and chronic vascular diseases, and to enhance tissue repair and regeneration. Common revascularization therapies include the administration of angiogenic factors, such as vascular endothelial growth factor (VEGF)....
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Illinois BioNanotechnology Seminar Series Fall 2011: Mechanotransduction at Cell-Cell Contact
Online Presentations | 04 Apr 2012 | Contributor(s): Hamid Tabdili
Differential adhesion between cadherin subtypes expressed on cell surfaces is postulated to direct cell segregation during tissue morphogenesis. The studies described here used magnetic twisting cytometry and traction force microscopy to test the impact of cadherin binding selectivity on...
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Illinois BioNanotechnology Seminar Series Fall 2011: Deconvolving Stiffness in MEMS Pedestal Cell Mass Measurements
Online Presentations | 05 Dec 2011 | Contributor(s): Elise Corbin
The complex relationships between a cell's behavior and the physical properties of both itself and its environment have long been of interest. Specifically, the understanding the mechanisms through which a cell's physical properties influence cell growth, cell differentiation, cell cycle...
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Illinois BioNanotechnology Seminar Series Fall 2011: Investigating Dendritic Filopodial Dynamics in Highly Controlled Microenvironments
Online Presentations | 21 Jan 2012 | Contributor(s): Anika Jain
The establishment of the intricate wiring of the nervous system relies on filopodial navigation to form complex interconnections between neurons. Until recently, cellular level investigations into filopodial dynamics had focused primarily on axonal growth cone filopodia. Here we focus on their...
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[Illinois] BioNanotechnology Seminar Series Fall 2012: Understanding and Controlling Fibrotic Myocardium
Online Presentations | 26 Nov 2012 | Contributor(s): Guy Genin
Hypertension kills 1 in every 5000 Americans each year and affects the majority of those over the age of 55. Following prolonged hypertension, cardiac fibroblasts within the heart convert to myofibroblasts, a larger, contractile phenotype that produces fibrous connective tissue and thereby...
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[Illinois] BioNanotechnology Seminar Series Fall 2012: Label-Free Electronic Detection of Cancer Biomarkers Using Silicon Nanowire Arrays
Online Presentations | 18 Dec 2012 | Contributor(s): Brian Dorvel
Improving the performance and lowering the analyte detection limits of optical and electronic biosensors is essential for advancing wide ranging applications in diagnostics and drug discovery. One of these diagnostic platforms, based upon microfluidics coupled to ion-selective field effect...
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[Illinois] Bionanotechnology Seminar Series Fall 2012: Mechanical Property Characterization for 3D Collagen Cancer Cell Cultures
Online Presentations | 08 Mar 2013 | Contributor(s): Yue Wang
The tumor microenvironment is mechanically modified during cancer progression. Imaging of tumor mechanical environment will provide new information for early cancer diagnosis. However, it is less clear how the mechanical environment is tuned in cancer. The goal of this study is to understand more...