PhysiCell simulation of GBM tumour under oHSV1 treatment

By Adrianne Jenner1; Randy Heiland2; Paul Macklin2

1. Queensland University of Technology 2. Indiana University

Simulation for GBM fragment growth under oHSV1 treatment published in Jenner et al. (2021)

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Version 1.0 - published on 28 Mar 2021

doi:10.21981/9261-SM49 cite this

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Abstract

Oncolytic viruses (OVs) - which directly infect and kill tumour cells while stimulating an immune response - are an emerging immunotherapy currently being investigated for the treatment of central nervous system cancers including glioblastoma (GB). We have constructed a quantitative representation of this treatment using PhysiCell - an open-source physics based cell simulator (physicell.org). This simulation here runs the OV on a fragment made up of 50% densely populated tumour cell regions and 50% sparely populated tumour cell regions. 

Cite this work

Researchers should cite this work as follows:

  • Adrianne Jenner, Randy Heiland, Paul Macklin (2021), "PhysiCell simulation of GBM tumour under oHSV1 treatment," https://nanohub.org/resources/ohsv1gbmapp. (DOI: 10.21981/9261-SM49).

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Tags

  1. abm
  2. agent-based model
  3. cancer
  4. glioblastoma
  5. modelling
  6. nano/bio
  7. oncolytic virus
  8. PhysiCell
  9. Virus