[Illinois] Translational Nanomedicines Using Biomedical Nanomaterials
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Abstract
Nano-medicine is the term for the use of advanced bio- and nano-technologies for the development of medicines. In this seminar, smart translational nanomedicines using biomedical nanomaterials will be presented for drug delivery and tissue engineering applications. The first part will cover real-time bioimaging of hyaluronic acid (HA) derivatives using quantum dots. HA derivatives with a carboxyl group modification less than 25 mol% mainly accumulated in the liver, whereas highly modified HA derivatives evenly distributed in the body. On the basis of these findings, we successfully developed target specific HA – interferon α conjugate, HA - TRAIL conjugate, and HA - gold nanoparticle / interferon α complex for the treatment of liver diseases such as hepatitis C virus infection and liver cirrhosis. In the second part, in situ formation and modular modification of HA hydrogels using the host-guest interaction between polyamine (PA) and cucurbit[6]uril (CB[6]) will be presented for genetically engineered mesenchymal stem cell (eMSC) cancer therapy. The released interleukin 12 (IL-12) from the eMSCs encapsulated in the CB[6]/PA-HA hydrogels effectively inhibited the tumor growth with prolonged survival periods. All these smart nanomedicines will be discussed for further clinical development with recent other research topics in collaboration with Harvard Medical School.
Bio
Professor Sei Kwang Hahn obtained his B.S., M.S., and Ph.D. in the Department of Chemical and Biomolecular Engineering at KAIST. As the youngest Ph.D. at LG Chemical group in 1996, he started his research on biodegradable polymers and then sustained release formulation of hGH. From 2001, he did his post-doctoral research with Prof. Allan Hoffman in the Bioengineering Department at the University of Washington. After that, he worked for long acting formulation of various biopharmaceuticals at Chugai Pharmaceutical Co., Hoffman-La Roche group in Japan for more than three years. Since 2005, he has worked as a professor in the Department of Materials Science and Engineering and an adjunct professor at the School of Interdisciplinary Bioscience and Bioengineering, POSTECH. He worked as a consultant for Johnson & Johnson, Ethicon in 2008 and made a collaboration contract for siRNA delivery with Hoffman-La Roche in 2009. From 2012, he has worked in the Wellman Center for Photomedicine, MGH and Harvard Medical School as a visiting professor. He became the SeAh Young Chair Professor of POSTECH in 2012 and the tenured professor at POSTECH in 2013.
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University of Illinois at Urbana-Champaign