Multiscale model of the different modes of invasion

Simulate 2D/3D cancer cell invasion in extracellular matrix with PhysiBoSS

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Version 0.5 - published on 05 Aug 2022

doi:10.21981/8XSC-YY37 cite this

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Abstract

We present here a model of tumor cell invasion simulated within PhysiBoSS, a multiscale
framework which combines agent-based modeling and continuous time Markov processes applied on
Boolean networks. With this model, we aim to study the different modes of cell migration through an
extracellular matrix by considering both spatial information obtained from the agent-based simulation and
intracellular regulation obtained from the solutions of the Boolean model.

References

https://academic.oup.com/bioinformatics/article/35/7/1188/5087713 G. Letort, A. Montagud, G. Stoll, R. Heiland, E. Barillot, P. Macklin, A. Zinovyev, L. Calzone, PhysiBoSS: a multi-scale agent-based modelling framework integrating physical dimension and cell signalling, Bioinformatics, Volume 35, Issue 7, 01 April 2019, Pages 1188–1196, https://doi.org/10.1093/bioinformatics/bty766

https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1005991A. Ghaffarizadeh, R. Heiland, S.H. Friedman, S.M. Mumenthaler, and P. Macklin. PhysiCell: an open source physics-based cell simulator for 3-D multicellular systems. PLoS Comput. Biol. 14(2):e1005991, 2018. DOI: 10.1371/journal.pcbi.1005991

https://joss.theoj.org/papers/10.21105/joss.01408 R. Heiland, D. Mishler, T. Zhang, E. Bower, and P. Macklin. xml2jupyter: Mapping parameters between XML and Jupyter widgets. Journal of Open Source Software 4(39):1408, 2019. DOI: 10.21105/joss.01408

https://pubmed.ncbi.nlm.nih.gov/25893299/ Lodillinsky C, Infante E, Guichard A, et al. p63/MT1-MMP axis is required for in situ to invasive transition in basal-like breast cancer. Oncogene. 2016;35(3):344-357. doi:10.1038/onc.2015.87

https://www.nature.com/articles/s42005-019-0198-5 Moitrier, S., Pricoupenko, N., Kerjouan, A. et al. Local light-activation of the Src oncoprotein in an epithelial monolayer promotes collective extrusion. Commun Phys 2, 98 (2019).

https://doi.org/10.1101/2022.01.06.468363 PhysiBoSS 2.0: a sustainable integration of stochastic Boolean and agent-based modelling frameworks, Miguel Ponce-de-Leon, Arnau Montagud, Vincent Noël, Gerard Pradas, Annika Meert, Emmanuel Barillot, Laurence Calzone, Alfonso Valencia, bioRxiv 2022.01.06.468363

Cite this work

Researchers should cite this work as follows:

  • Marco Ruscone, Arnau Montagud, Laurence Calzone, Vincent Noel (2022), "Multiscale model of the different modes of invasion," https://nanohub.org/resources/invasiongui. (DOI: 10.21981/8XSC-YY37).

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  1. PhysiBoSS
  2. PhysiCell
  3. tool:ecmsimul
  4. tool:invasiongui
  5. tool:physicellecm