The aim of the nanoMFG Node, hosted at the University of Illinois at Urbana-Champaign (UIUC) in partnership with the University of California at Berkeley, is to develop computational software tools aimed at creating smart, model-driven and experimentally informed nanomanufactured structures and devices. To simulate every step of the manufacturing process of a nano-enabled product. The node’s mission is to be the engine for design, simulation, planning, and optimization of nano-manufacturing processes. This will be accomplished by developing tools using a layered computational infrastructure comprising nanoscale transport phenomena models, process models, uncertainty quantification framework, application and empirical validation of process models, tools for multiscale transport phenomena, and tools for nanoscale self-assembly.