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BME 695N Lecture 15: Nanodelivery of therapeutic genes & molecular biosensor feedback control systems
Online Presentations | 30 Oct 2007 | Contributor(s):: James Leary
Outline:Introduction and overviewSome of the advantages of therapeutic genesSome of the advantages of molecular biosensor feedback control systemsWhy a nanodelivery approach is appropriateThe therapeutic gene approachWhat constitutes a "therapeutic gene" ?Transient versus stable expression...
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BME 695N Lecture 14: Challenges of proper drug dosing with nanodelivery systems
Online Presentations | 29 Oct 2007 | Contributor(s):: James Leary
Outline:Overview of drug dosing problemProblems of scaling up doses from animal systemsBasing dosing on size, area, weight of recipientVast differences between adults in terms of genetics, metabolismDosing in children – children are NOT smaller adults!Pharmacokinetics – drug distribution,...
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KIST/PU Design and Performance of Bioresponsive Nanocarriers with Tunable Reactivity for Drug and Gene Delivery
Online Presentations | 23 Oct 2007 | Contributor(s):: Dave Thompson
Our lab has focused on the development of bioresponsive nanocarriers that are designed to release their cargo upon entry into acidic environments such as those found in cellular endosomes and sites of poor circulation. Computational methods have been used to design vinyl ether lipids of varying...
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KIST/PU Bridging Nonlinear Optical Imaging and Nanotechnology with Medicine
Online Presentations | 23 Oct 2007 | Contributor(s):: Ji-Xin Cheng
Our interdisciplinary research develops and utilizes state-of-the-art optical imaging techniques and nanotechnology to tackle compelling biomedical problems highly related to human health. Research in my group covers diagnosis, treatment, and mechanistic study of diseases.
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KIST/PU Multi-Component, Multi-Functional Nanomedical Systems for Drug/Gene Delivery
Online Presentations | 23 Oct 2007 | Contributor(s):: James Leary
In this brief paper we describe some of our recent efforts to construct multi-component, multi-functional nanomedical systems for delivery of therapeutic genes. We first describe the general philosophy of our approach. Then we describe three specific aspects of the overall construction in simple...
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KIST/PU Tumor-Homing Chitosan-Based Nanoparticles for Cancer Theragnosis; Imaging, Drug Delivery and Therapy
Online Presentations | 23 Oct 2007 | Contributor(s):: Ick Chan Kwon
We have prepared self-assembled polymeric drug carriers containing fluorophore and loaded drugs for theragnostic imaging of tumors. This new type of polymeric drug carriers visualizes the accumulation of carriers at tumor sites, and evaluates therapeutic efficacies, and thereby providing an...
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KIST/PU Introduction to Global Research Laboratory (GRL) Program: Molecular Imaging and Nanomedicine for Theragnosis using Nano-Bio Materials
Online Presentations | 23 Oct 2007 | Contributor(s):: Kui Won Choi
The Global Research Laboratory (GRL) program was initiated by the Korea Foundation for International Cooperation of Science and Technology (KICOS) in 2006. The GRL program has been designed to develop fundamental and original technologies through international collaborative research between...
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KIST/PU 2nd Annual Symposium: Molecular Imaging and Theragnosis
Workshops | 23 Oct 2007
This symposium presents an overview of the research of the Global Research Laboratory (GRL), a program that reflects a direct collaboration of scientific research between South Korea (Korea Institute of Science and Technology [KIST] and its affiliated research institutions) and the United States...
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BME 695N Lecture 12: Introduction to X-ray Photoelectron Spectroscopy and the Examples of Biologically-Relevant Applications
Online Presentations | 19 Oct 2007 | Contributor(s):: Dmitry Zemlyanov
With Dmitry Zemlyanov as guest lecturer.
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BME 695N Lecture 11: Construction of biomolecule conjugated nanoparticles
Online Presentations | 30 Sep 2007 | Contributor(s):: Don Bergstrom
With Donald E. Bergstrom as guest lecturer.
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BME 695N Lecture 9: Atomic Force Microscopy (AFM) for Nanomedical Systems (cells and nanoparticles)
Online Presentations | 30 Sep 2007 | Contributor(s):: Helen McNally
What Helen McNally as guest lecturer.
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BME 695N Lecture 6: Rare-event targeting of cells in-vitro and in-vivo
Online Presentations | 26 Sep 2007 | Contributor(s):: James Leary
Outline:Assessing nanomedical system (NMS) targeting at the single cell levelFluorescent labeling of NMSsFirst estimates of NMS binding by fluorescence microscopyInternal of external binding by confocal microscopySingle-cell image/confocal analysisFlow cytometric quantitation of NMS binding to...
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BME 695N Lecture 10: Nanomaterials for core design
Online Presentations | 26 Sep 2007 | Contributor(s):: James Leary
Outline:IntroductionCore building blocksFunctional coresFunctionalizing the core surfaceFerric oxide coresParamagnetic coresSuperparamagnetic coresFerric nanorodsAdvantages and disadvantagesC60 and carbon nanotubesSize and structure of C60Elongation of C60 into carbon nanotubesAdvantages and...
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BME 695N Lecture 8: Technologies for measuring nanomedical systems on/within cells
Online Presentations | 24 Sep 2007 | Contributor(s):: James Leary
Outline:Introduction to measuring technologies for nanomedical system interaction with cellsThe importance of quantitative or at least semi-quantitative single cell measurementsto detect presence and location of nanomedical systemsBelow "optical limit" imagingRequirements on the NMS to have X-ray...
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BME 695N Lecture 7: Normal & facilitated cell entry mechanisms
Online Presentations | 15 Sep 2007 | Contributor(s):: James Leary
Outline:IntroductionThe general problem of cell entryChoosing modes of cell entryHow does Nature do it? (biomimetics)Non-specific uptake mechanismsPinocytosis by all cellsPhagocytosis by some cellsReceptor mediated uptakeReceptor mediated transport of desired moleculesExample- transferrin...
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BME 695N Lecture 5: Cell Targeting
Online Presentations | 12 Sep 2007 | Contributor(s):: James Leary
Outline:Overview: targeting nanosystems to cellsAntibody targetingPeptide targetingAptamer targetingAntibodies – polyclonal and monoclonalWhere do antibodies come from – in nature?How do we make them in the laboratory?Monoclonal antibodiesTherapy problems with mouse monoclonal...
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BME 695N Lecture 4: Designing "Theragnostic" Systems
Online Presentations | 04 Sep 2007 | Contributor(s):: James Leary
Outline:Bridging the gap between diagnostics and therapeuticsHow conventional medicine is practiced in terms of diagnostics and therapeuticsThe consequences of separating diagnostics and therapeuticsA new approach – "theragnostics" (or "theranostics")Examples of current theragnostic...
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BME 695N Lecture 3: Overview of Basic Nanomedical Systems Design
Online Presentations | 29 Aug 2007 | Contributor(s):: James Leary
Outline:Nanomedical systems – levels of challengesEssential elements of a nanomedical systemRequirements for specific cell targetingConsequences of mis-targetingEngineering around the consequences of mis-targetingSome ways to lower mis-targeting to non-diseased cells
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BME 695N: Engineering Nanomedical Systems (Fall 2007)
Courses | 03 Aug 2007 | Contributor(s):: James Leary
This course will cover the basic concepts of design of integrated nanomedical systems for diagnostics and therapeutics. Topics to be covered include: why nanomedical approaches are needed, cell targeting strategies, choice of core nanomaterials, technologies for testing composition and...
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BME 695N Lecture 2: Basic Concepts of Nanomedical Systems
Online Presentations | 28 Aug 2007 | Contributor(s):: James Leary
Outline: Features of NanomedicineBottoms up rather than top down approach to medicine Nano-tools on the scale of molecules Cell-by-cell repair approach – regenerative medicine Feedback control system to control drug dosing Elements of good engineering designWhenever possible, use a general design...