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BME 695L Lecture 11: Assessing Nanotoxicity at the Single Cell Level
Online Presentations | 27 Oct 2011 | Contributor(s):: James Leary
See references below for related reading.11.1 Need for single cell measures of nanotoxicity11.1.1 There is more than one way for a cell to die...11.1.2 "Necrosis" vs. "Apoptosis"11.1.3 There...
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BME 695L Lecture 10: Nanodelivery of Therapeutic Genes and Molecular Biosensor Feedback Control Systems
Online Presentations | 26 Oct 2011 | Contributor(s):: James Leary
See references below for related reading.10.1 Introduction and overview10.1.1 Some of the advantages of therapeutic genes10.1.2 Some of the advantages of molecular biosensor feedback control...
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BME 695L Lecture 9: Challenges of Proper Drug Dosing with Nanodelivery Systems
Online Presentations | 19 Oct 2011 | Contributor(s):: James Leary
See references below for related reading.9.1 Overview of drug dosing problem9.1.1 Problems of scaling up doses from animal systems9.1.2 Basing dosing on size, area, weight of...
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BME 695L: Engineering Nanomedical Systems
Courses | 31 Aug 2011 | Contributor(s):: James Leary
This course will cover the basic concepts of design of integrated nanomedical systems for diagnostics and therapeutics. Topics to be covered include: why nanomedical approaches are needed, cell targeting strategies, choice of core nanomaterials, technologies for testing composition and structure...
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Qingjiang Guo
https://nanohub.org/members/46844
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how do i make my own simulation
Q&A|Closed | Responses: 1
i am trying to make my own simulation of a drug delivery sysytem and cant seem to figure out how to make my own simulation. can anyone please help me with this?
https://nanohub.org/answers/question/511
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Waqas Ali
Waqas Ali is a PhD student in University of Texas at Arlington, US since Fall 2010. He did BSc. Electrical Engineering from University of Engineering and Technology Lahore, Pakistan in September...
https://nanohub.org/members/37855
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Strategies for Preparation and Manufacture of Polymer-based Nanoparticulate Formulations
Online Presentations | 21 Jul 2008 | Contributor(s):: Stephen R. Byrn
Nanoparticles hold great promise for drug delivery applications. Several polymer-based formulations containing nanoparticles are in late phase development or on the market. In fact, polymer dispersions provide one of the best methods to prepare nanoparticles of small-molecule organic drugs....
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Development of Highly Porous Large Polymeric Microparticles for Sustained Local Drug Delivery to the Lung
Online Presentations | 10 Jul 2008 | Contributor(s):: Yoon Yeo
In this presentation, I will introduce a new way of making highly porous large polymeric microparticles recently developed in my lab. These microparticles exhibited desirable aerodynamic properties, reduced macrophage uptake, encapsulated a drug efficiently, and provided sustained drug release...
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Design of Multi-Component, Multi-Functional Nanomedical Systems for Drug/Gene Delivery and Theragnostics
Online Presentations | 02 Jul 2008 | Contributor(s):: James Leary
Multi-component and multifunctional nanoparticles hold great promise for drug/gene delivery and simultaneous diagnostics and therapeutics ("theragnostics"). Sophisticated multi-component systems can employ collections of specialized molecules in a nanodelivery system whose actions can be...
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Functionalized Nanomaterials at the Interface of Biology and Technology
Online Presentations | 24 Apr 2008 | Contributor(s):: Dean Ho, National Center for Learning & Teaching in Nanoscale Science & Engineering
Nanomaterials, such as block copolymeric membranes and nanodiamonds, can be engineered for a broad range of applications in energy and medicine. This presentation will highlight the relevance of these materials as foundations for device fabrication across the spectrum of biology and technology....
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KIST/PU A bi-functional block copolymer hydrogels and micelles for protein and drug delivery
Online Presentations | 28 Nov 2007 | Contributor(s):: Doo Sung Lee
Novel biodegradable & injectable poly(β-amino ester)-poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolactone)-poly(β-amino ester)(PAE-PCL-PEG-PCL-PAE) bi-functional, pH/temperature-sensitive, block copolymer hydrogels were prepared and applied to protein and drug delivery. In this...
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BME 695N Lecture 19: In vivo model systems to study nanomedical approaches to cancer detection and intervention
Online Presentations | 27 Nov 2007 | Contributor(s):: Deborah W Knapp
With Deborah Knapp as guest lecturer.
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Engineering Nanomedical Systems
Online Presentations | 16 Nov 2007 | Contributor(s):: James Leary
This tutorial will cover general problems and approaches to the design of engineered nanomedical systems. An example to be covered is the engineering design of programmable multilayered nanoparticles (PMNP) to control a multi-sequence process of targeting to rare cells in-vivo, re-targeting to...
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BME 695N Lecture 18: Designing nanodelivery systems for in-vivo use
Online Presentations | 12 Nov 2007 | Contributor(s):: James Leary
Outline:Overview – the in-vitro to ex-vivo to in-vivo paradigm In-vitro - importance of choosing suitable cell lines Ex-vivo – adding the complexity of in-vivo background while keeping the simplicity of in-vitro In-vivo - all the complexity of ex-vivo plus the “active” components of a real...
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BME 695N Lecture 17: Assessing nanotoxicity at the single cell level
Online Presentations | 06 Nov 2007 | Contributor(s):: James Leary
Outline:Outline – the need for single cell measures of nanotoxicity There is more than one way for a cell to die... Necrosis" vs. "Apoptosis" There are other forms of "toxicity" Some other challenges in measuring toxicity of nanomaterialsNecrosis vs. Apoptosis mechanisms Necrosis is unplanned...
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BME 695N Lecture 16: Assessing drug efficacy at the single cell level
Online Presentations | 02 Nov 2007 | Contributor(s):: James Leary
Outline:Introduction and overviewNanomedical treatment at the single cell level requires evaluation at the single cell levelFor evaluation purposes, does structure reveal function?The difficulty of anything but simple functional assaysThe need for assays which at least show correlation to...
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BME 695N Lecture 15: Nanodelivery of therapeutic genes & molecular biosensor feedback control systems
Online Presentations | 30 Oct 2007 | Contributor(s):: James Leary
Outline:Introduction and overviewSome of the advantages of therapeutic genesSome of the advantages of molecular biosensor feedback control systemsWhy a nanodelivery approach is appropriateThe therapeutic gene approachWhat constitutes a "therapeutic gene" ?Transient versus stable expression...
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BME 695N Lecture 14: Challenges of proper drug dosing with nanodelivery systems
Online Presentations | 29 Oct 2007 | Contributor(s):: James Leary
Outline:Overview of drug dosing problemProblems of scaling up doses from animal systemsBasing dosing on size, area, weight of recipientVast differences between adults in terms of genetics, metabolismDosing in children – children are NOT smaller adults!Pharmacokinetics – drug distribution,...
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KIST/PU Bridging Nonlinear Optical Imaging and Nanotechnology with Medicine
Online Presentations | 23 Oct 2007 | Contributor(s):: Ji-Xin Cheng
Our interdisciplinary research develops and utilizes state-of-the-art optical imaging techniques and nanotechnology to tackle compelling biomedical problems highly related to human health. Research in my group covers diagnosis, treatment, and mechanistic study of diseases.