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2005 Molecular Conduction and Sensors Workshop

Sensitivity Amplification in Biosensors using Nanoparticles and Enzymatic Macromolecules

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Last 12 Months: updated 01 Oct, 2008
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Contributor(s) Cagri Savran
Purdue University, West Lafayette
Abstract We present non-invasive methods for improving the sensitivity of label-free biosensors that offer the advantage of rapid and real-time detection but suffer from relatively low sensitivity. We present detection of cancer markers using the Quartz Crystal Microbalance and demonstrate that 2 order-of-magnitude amplification in sensitivity can be achieved by forming sandwich or "piggy back" layers using antibodies and functionalized gold nanoparticles. We also discuss detection of aptazymes i.e. RNA-based enzymatic macromolecules and their potential as signal amplifying agents in biosensors.
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  • Savran, Cagri (2005), "Sensitivity Amplification in Biosensors using Nanoparticles and Enzymatic Macromolecules," http://www.nanohub.org/resources/533/.

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Date posted 01 Sep, 2005
Time 03:00 PM, July 27, 2005
Location Purdue University, West Lafayette, IN
Type Online Presentations
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  • 10.0 Ranking Workshops Part of: 2005 Molecular Conduction and Sensors Workshop

    2005 Molecular Conduction and Sensors Workshop

    Type Workshops
    Date 25 May, 2005
    Avg. Rating 0.0 out of 5 stars  (0)
    Rate this

    This is the 3rd in a series of annual workshops on Molecular Conduction. The prior workshops have been at Purdue University, W. Lafayette, IN (2003) and Nothwestern University, Evanston, IL (2004). The workshop has been an informal and open venue for discussing new results, key challenges, and …

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