Sending report ...2008 BioNano Technology and Pharmaceuticals
Nanocomposite-Modified Electrodes for Sensing Biological Analytes
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| Contributor(s) | V. Yegnaraman Central Electrochemical Research Institute (CECRI), Karaikudi |
|---|---|
| Abstract | Electrochemical sensing of analytes is mostly enabled by transducers based on potentiometry and amperometry. In this, design of sensing (working) electrode is of utmost importance since it only decides the sensitivity and selectivity features of the sensor. Chemical modification of the electrode surface, especially with nanosized materials constitutes an important approach to achieve the desired goals. Clinical diagnostics, involving rapid analysis of physiologically important molecules is a contemporary area attracting the electrochemists.
Carbon electrodes have been modified with nanocomposites of poly (3,4-ethylenedioxy thiophene (PEDOT) and gold nanoparticles were prepared and characterized. The modified electrode enables amperometric detection of dopamine (DA) at nanomolar levels and exhibits excellent selectivity for DA over ascorbic acid. Further the modified electrode is able to estimate amperometrically μM concentrations of uric acid in presence of ascorbic acid. The efficacy of the electrodes has been tested with real samples. Analysis of another important molecule, hydrogen peroxide at nanomolar levels has been achieved using carbon electrode modified with a nanocomposite comprising nanosized Prussian Blue moieties and Au nanoparticles. Carbon electrodes have been advantageously employed to detect μM levels of triclosan, an antimicrobial agent in healthcare formulations. An electrochemical sensor for the estimation of glycated hemoglobin has been developed for the first time and it is expected to play an important role in the management of diabetes mellitus. Some interesting results of these investigations will be discussed. |
| Biography | 
Dr. V. Yegnaraman is currently heading the Electrodics and Electrocatalysis division of the Central Elerctrochemical Research Institute, Karaikudi. He passed M.S c in Chemistry from the Banaras Hindu University, Varanasi. Later from the same university, he obtained his Ph.D. degree for his studies on “Exponential relaxation techniques for corrosion rate determination”. He has more than three decades of research experience in the areas of electroanalytical chemistry, modified electrodes and electrochemical sensors.
He has been associated with the know-how development for electrochemical marking of metals, indigenous reference electrode for ECG measurements, Ag/AgCl electrodes for ELFE sensor, electrochemical sensors for the estimation of antimicrobial agent in healthcare formulations and glycated hemoglobin in blood samples. He has more than 65 publications in peer-reviewed/SCI journals and has four Indian patents. He teaches B.Tech. and M.Tech. students in Electrochemical Engineering of Anna University. He was awarded Exchange Fellowship to visit CNRS (France, 1990), Raman Research Fellowship to work in Rutgers University (USA, 1995) and INSA-DFG Fellowship to work in Kurt-Schwabe Institute (Germany, 2007). He has served as Secretary and later as Vice-President of the Society for Advancement of Electrochemical Science and Technology (SAEST). He is a Life Fellow of SAEST. He has rendered editorial service to journals, Bulletin of Electrochemistry, Trans SAEST, Current Titles in Electrochemistry. |
| Cite this work | If you reference this work in a publication, please cite as follows: |
| Date posted | 30 Jul, 2008 |
| Time | 05:15 PM, March 13, 2008 |
| Location | Centre for Cellular and Molecular Biology, Hyderabad, India |
| Type | Online Presentations |
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7.4 Ranking Workshops
Part of: 2008 BioNano Technology and Pharmaceuticals
2008 BioNano Technology and Pharmaceuticals
Type Workshops Contributor(s) Pankaj Sharma, Nalam Madhusudhana Rao Date 06 Aug, 2008 Avg. Rating (0) Rate this The purpose of this symposium is to bring together top scientists from India and the United States to present their latest work and to discuss future international scientific collaborative partnerships. This one and a half day symposium will also feature a special second half day mini-symposium and …
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