Sending report ...NCN Nano-Devices for Medicine and Biology: Research Seminars
Micro-scaled Biochips with Optically Active Surfaces for Near and Far-field Analysis of Cellular Fluorescence
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Supporting Documents
- Presentation (with audio) (SWF)
- Presentation Slides (PDF, 2.9 Mb)
- Podcast (video) What's this? (MP4, 68.82 Mb)
- Podcast (audio) What's this? (MP3, 26.45 Mb)
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| Contributor(s) | Huw Summers Cardiff University, Wales, UK |
|---|---|
| Abstract | The integration of thin (< 100 nm) metal films with micro-scale optical waveguides provides a route to controlled spatial excitation of cellular fluorescence within a biochip platform. Surface bound electron-plasma oscillations (surface plasmon waves) interact with photons to produce an evanescent field localized within 100nm of the chip surface. These plasmon fields can therefore be used as a near-field probe of analytes situated at the surface e.g. surface plasmon resonance (SPR) sensing. If a grating with sub-wavelength periodicity is fabricated at the surface then coupling of the plasmons to free-space photons can be achieved and a highly directional beam of light is produced. We have been developing surface-active biochips using these processes to provide selective excitation in the near or far field of fluorescently- labeled cells. These chips combine a number of commonly used techniques such as SPR, TIRF and epi-fluorescence within a single device and have the potential to provide sub-cellular discrimination of excitation in 3-D. |
| Biography | Dr. Summers is a biophotonics physicist, who among other things, works on the UK Optical Biochip project designing small, micro- fluidic, optical biochip cytometers. He is spending a mini- sabbatical with Dr. Leary at Discovery Park during the month of July with collaborations to continue in the coming year. |
| Cite this work | If you reference this work in a publication, please cite as follows: |
| Date posted | 31 Aug, 2007 |
| Time | 04:00 PM, July 31, 2007 |
| Location | Birck Nanotechnology Building, Room 1001 |
| Type | Online Presentations |
| Tags |
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