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Molecular Conduction Workshop 2007

MCW07 Silicon Based Nanopore Sensors for Detection of DNA Molecules

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Last 12 Months: updated 01 Jun, 2008
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Contributor(s) Samir Iqbal, Demir Akin, Rashid Bashir
Purdue University, West Lafayette
Abstract Solid-state nanopores have emerged as possible candidates for next-generation DNA sequencing devices. In this talk, we will review our recent work in development of solid-state nanopore channels that are selective towards single strand DNA (ssDNA). Nanopores functionalized with a 'probe' of hair-pin loop DNA can, under an applied electrical field, selectively transport short lengths of 'target' ssDNA that are complementary to the probe. Even a single base mismatch between the probe and the target results in longer translocation pulses and a significantly reduced number of translocation events. Our single molecule measurements allow us to separately measure the molecular flux and the pulse duration, providing a tool to gain fundamental insight into the channel-molecule interactions. The results can be explained in the conceptual framework of diffusive molecular transport with particle-channel interactions.
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  • Iqbal, Samir; Akin, Demir; Bashir, Rashid (2007), "MCW07 Silicon Based Nanopore Sensors for Detection of DNA Molecules," http://www.nanohub.org/resources/3079/.

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Date posted 11 Sep, 2007
Time 01:25 PM, July 19, 2007
Location Burton Morgan Building, Purdue University, West Lafayette, IN
Type Online Presentations
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  • 0.0 Ranking Workshops Part of: Molecular Conduction Workshop 2007

    Molecular Conduction Workshop 2007

    Type Workshops
    Date 02 May, 2007
    Avg. Rating 0.0 out of 5 stars  (0)
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    This is the 5th in a series of annual workshops on Molecular Conduction – the prior workshops have been in W. Lafayette (2003, 2005), Evanston (2004) and Virginia (2006). The workshop has been an informal and open venue for discussing new results and key challenges. Two years ago, we expanded the …

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