Sending report ...Nanotechnology 501 Lecture Series
Molecular Interferometry
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Supporting Documents
- Presentation (with audio) (SWF)
- Presentation Slides (PDF, 4.75 Mb)
- Podcast (video) What's this? (MP4, 46.06 Mb)
- Podcast (audio) What's this? (MP3, 27.15 Mb)
| Contributor(s) | David D. Nolte Purdue University, West Lafayette |
|---|---|
| Abstract | While single-molecule detection through fluorescence has now become common-place, there has been no analogous single-molecule capability using direct detection approaches such as interferometry. This limitation is slowly yielding to high-speed interferoemtric detection that is pushing the detection into the small-number limit. In this tutorial, I will outline the basic principles of interferometry and their application to the detection of biomolecules on solid surfaces. The use of high-speed detection on a spinning disc provides an immediate 50 dB noise suppression that is hard to match with high-gain approaches such as surface-plasmon resonance or Fabry-Perots. I will describe the application of spinning-disc interferometry (SDI) on the BioCD to detect antigen binding to immobilized antibodies by establishing phase quadrature conditions in common-path interferometry that is impervious to mechanical perturbations. The high-speed disc approach is developing in parallel with an imaging approach called molecular interferometric imaging (MI2) that directly images molecular patterns on surfaces with sensitivities down to 100 molecules per pixel |
| Sponsored by | NCN@Purdue Student Leadership Team |
| Cite this work | If you reference this work in a publication, please cite as follows: |
| Date posted | 26 Jun, 2007 |
| Time | 02:00 PM, May 28, 2007 |
| Location | EE Building, Room 317 |
| Type | Online Presentations |
| Tags |
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Posted on 25 June, 2007 by Joseph M. Cychosz
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9.5 Ranking Series
Part of: Nanotechnology 501 Lecture Series
Nanotechnology 501 Lecture Series
Nanotechnology 501 is a series of lectures designed to provide an introduction to nanotechnology. This series is similar to our popular Nanotechnology 101 series, but directed at the graduate student/professional level.
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