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Purdue OSC Cancer Prevention Seminar Series

Antiestrogenic Conjugates as New Breast Cancer Chemoprevention Agents

This resource has a 6.3 Ranking

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Last 12 Months: updated 01 Sep, 2008
Users: 100
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Avg. Review: 0.0 out of 5 stars
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Contributor(s) Ross Weatherman
Purdue University, West Lafayette
Abstract Tamoxifen is the first drug specifically approved for the prevention of cancer and arguably the most successful anticancer drug of all time. Although millions of breast cancer patients have benefited from tamoxifen therapy, there are side effects that hinder the broad use of tamoxifen as a chemopreventive agent. We have developed analogs of tamoxifen and other estrogenic compounds conjugated to polymer scaffolds and have found that these conjugates can still inhibit breast cancer cell proliferation with mechanisms distinct from any known antiestrogen. Changing the type of polymer changes the cellular localization of the conjugate and its activity. With novel mechanisms of action, we hypothesize that these conjugates may exhibit different physiological responses than tamoxifen and serve as superior breast cancer chemopreventive agents
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  • Weatherman, Ross (2007), "Antiestrogenic Conjugates as New Breast Cancer Chemoprevention Agents," http://www.nanohub.org/resources/2366/.

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Date posted 08 Mar, 2007
Time 11:30 AM, February 15, 2007
Location Burton Morgan Building, Room 121
Type Online Presentations
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  • 5.4 Ranking Series Part of: Purdue OSC Cancer Prevention Seminar Series

    Purdue OSC Cancer Prevention Seminar Series

    Type Series
    Date 01 Mar, 2007
    Avg. Rating 0.0 out of 5 stars  (0)
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    The goal of the OSC Cancer Prevention Seminar Series is to provide an environment that facilitates increased collaboration of these scholarly efforts to promote further interdisciplinary interactions and research that lead to development of innovative methods for smoking cessation and program …

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