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James Leary
| Contributions | 24 |
|---|---|
| Affiliation | Purdue University, West Lafayette |
| Web Site | https://engineering.purdue.edu/BME/People/viewPersonById?resource_id=5544 |
| Biography | Dr. Leary moved to Purdue on July 1, 2005 and became the SVM (School of Veterinary Medicine) Endowed Professor of Nanomedicine and a tenured full professor in the Department of Basic Medical Sciences and the Weldon School of Biomedical Engineering. He is also a Member of the Bindley Biosciences Center, Birck Nanotechnology Center, and the Oncological Science at Discovery Park where his laboratories are located. He is also a Member of the Purdue Cancer Center. For the previous 10 years Dr. Leary was a tenured Professor of Internal Medicine (Division of Infectious Diseases), Pathology, Biophysics, Microbiology & Immunology, and Human Biological Chemistry & Genetics as well as an Assistant Director of the Biomedical Engineering Center, an Affiliated Senior Scientist in the Sealy Centers for Molecular Sciences, Structural Biology, Cancer Cell Biology, Vaccine Development, and the Program in Bioinformatics. He also served as Assistant Vice President of Research for Advanced Technology. Prior to this position Dr. Leary was an Assistant and Associate Professor of Experimental Pathology at the University of Rochester Medical School. Dr. Leary's research and teaching career as a professor spans more than 27 years. His original training includes an aerospace engineering degree from M.I.T., postgraduate work in astrophysics and a Ph.D. in Biophysics from Penn State University with a postdoctoral fellowship at Los Alamos National Laboratory. His research has been continuously funded by NIH for more than 25 years. He is the holder of 7 U.S. Patents, with 3 currently pending and is the author of numerous papers in the fields of high-throughput technologies, minimal residual disease monitoring, developmental immunology, cancer research, and nanomedicine. Dr. Leary has served on numerous national expert review panels for more than 20 years and is a frequently invited speaker at national and international scientific conferences. His current funded research spans three general areas: (1) development of new high-throughput screening technologies for genomics, proteomics, and drug discovery (2) microgenomics of adult human stem cells at the single cell level (the new field of “cytomics�), and (3) smart nano-engineered systems for single-cell drug/gene delivery for nanomedicine and vaccine development. As part of the third application area, he has been developing multilayered, smart nanosystems containing cell targeting, entry facilitation, and localization molecules with molecular biosensors controlling delivery of therapeutic genes into single cells. These are the subject of a number of peer-reviewed publications and pending patents. |
Contributions
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BME 695N Lecture 21: FDA and EPA Regulatory Issues
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27 Nov. 2007 | Online Presentations | Contributor(s): James Leary
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BME 695N Engineering Nanomedical Systems
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28 Aug. 2007 | Courses | Contributor(s): James Leary
This course will cover the basic concepts of design of integrated nanomedical systems for diagnostics and therapeutics. Topics to be covered include: why nanomedical approaches are needed, cell targeting strategies, choice of core nanomaterials, technologies for testing composition and structure …
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BME 695N Lecture 10: Nanomaterials for core design
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26 Sep. 2007 | Online Presentations | Contributor(s): James Leary
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BME 695N Lecture 13: Assessing Zeta Potentials
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29 Oct. 2007 | Online Presentations | Contributor(s): James Leary
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BME 695N Lecture 14: Challenges of proper drug dosing with nanodelivery systems
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29 Oct. 2007 | Online Presentations | Contributor(s): James Leary
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BME 695N Lecture 15: Nanodelivery of therapeutic genes & molecular biosensor feedback control systems
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30 Oct. 2007 | Online Presentations | Contributor(s): James Leary
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BME 695N Lecture 16: Assessing drug efficacy at the single cell level
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02 Nov. 2007 | Online Presentations | Contributor(s): James Leary
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BME 695N Lecture 17: Assessing nanotoxicity at the single cell level
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06 Nov. 2007 | Online Presentations | Contributor(s): James Leary
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BME 695N Lecture 18: Designing nanodelivery systems for in-vivo use
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12 Nov. 2007 | Online Presentations | Contributor(s): James Leary
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BME 695N Lecture 1: Need for New Perspectives on Medicine
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03 Aug. 2007 | Online Presentations | Contributor(s): James Leary
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BME 695N Lecture 20: GMP and issues of quality control manufacture of nanodelivery systems
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15 Nov. 2007 | Online Presentations | Contributor(s): James Leary
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BME 695N Lecture 2: Basic Concepts of Nanomedical Systems
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28 Aug. 2007 | Online Presentations | Contributor(s): James Leary
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BME 695N Lecture 3: Overview of Basic Nanomedical Systems Design
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29 Aug. 2007 | Online Presentations | Contributor(s): James Leary
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BME 695N Lecture 4: Designing "Theragnostic" Systems
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04 Sep. 2007 | Online Presentations | Contributor(s): James Leary
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BME 695N Lecture 5: Cell Targeting
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12 Sep. 2007 | Online Presentations | Contributor(s): James Leary
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BME 695N Lecture 6: Rare-event targeting of cells in-vitro and in-vivo
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26 Sep. 2007 | Online Presentations | Contributor(s): James Leary
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BME 695N Lecture 7: Normal & facilitated cell entry mechanisms
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15 Sep. 2007 | Online Presentations | Contributor(s): James Leary
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BME 695N Lecture 8: Technologies for measuring nanomedical systems on/within cells
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24 Sep. 2007 | Online Presentations | Contributor(s): James Leary
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Engineering Nanomedical Systems
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14 Mar. 2006 | Online Presentations | Contributor(s): James Leary
This tutorial will cover general problems and approaches to the design of engineered nanomedical systems. An example to be covered is the engineering design of programmable multilayered nanoparticles (PMNP) to control a multi-sequence process of targeting to rare cells in-vivo, re-targeting …
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Engineering Nanomedical Systems
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16 Nov. 2007 | Online Presentations | Contributor(s): James Leary
This tutorial will cover general problems and approaches to the design of engineered nanomedical systems. An example to be covered is the engineering design of programmable multilayered nanoparticles (PMNP) to control a multi-sequence process of targeting to rare cells in-vivo, re-targeting to …
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Ethics of Stem Cells and Therapeutic Cloning
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27 Nov. 2007 | Online Presentations | Contributor(s): James Leary
Invited lecture for Purdue University course SOC 573
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KIST/PU Multi-Component, Multi-Functional Nanomedical Systems for Drug/Gene Delivery
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23 Oct. 2007 | Online Presentations | Contributor(s): James Leary
In this brief paper we describe some of our recent efforts to construct multi-component, multi-functional nanomedical systems for delivery of therapeutic genes. We first describe the general philosophy of our approach. Then we describe three specific aspects of the overall construction in simple …
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Nanofactories - In - Situ Production of Therapeutic Genes...
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01 Sep. 2005 | Online Presentations | Contributor(s): James Leary
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Nanotechnologies, Science and Society: Promises and Challenges
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10 May. 2007 | Online Presentations | Contributor(s): James Leary
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